Visible symptoms of the disease (skin defects around fish head) occur in advanced stage of this disease. Presumably causes of this disease are 3 species of parasites: hexamita salmonis, hexamita truttae and hexamita intestinalis. They live and feed of organic wastes and they get to fish digestive tract with them. Reproduction of these parasites inside the fish depends on its immune system. The parasites attach to the wall of upper intestine their flagella. When fish immune system is weakened then the parasites rapid reproduce. Then they destroy intestinal mucosa and they expand to other internal organs. The parasites expand to fish head most of all. There they gradually damage tissues which rot. The skin cracks and there appears abscesses and open wounds.
The most effective method diagnosis is observation of fish intestine under a microscope (in magnification 200-400 times larger). The flagellates are well visible in this magnification – they move fast and unequally.
We need dissolve capsule in 0.2 litre warm water before application. We dose 1 capsule per every 50l water for disinfectant bath. We dose 1 capsule per every 100l water for preventive bath. This preparation isn't dangerous for plants.
We need give directly this drug orally or for food. Then the medicine is the most effective.
When the fish don't eat we may do curative baths. Then we dissolve the drug in warm water and we dose 5mg per every litre of the water. We do 3 times this bath every other day.
We dose 1 tablet per every 50l water. The curative bath we do for next 5 days. After this time we filter the water from aquarium through activated carbon and we do a partial water change in purpose of removal the drug from the water. We don't use this medicine together with other drugs/preparations.